Sunday, June 30, 2013

Cancer risk determined via detailed patient histories

CancerGene Connect online program estimates genetic cancer risk.
Researchers say that a genetic variation once dismissed as harmless turns out to be the first gene discovered to cause familial colorrectal cancer. UPI cc/Tom Lofgren?

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DALLAS, June 30 (UPI) -- Screening and knowing a person's genetic risk for certain cancers is an effective way to nip cancer in the bud, a U.S. cancer expect says.

Dr. David Euhus, clinical director of the Harold C. Simmons Cancer Center's Genetics Program at the University of Texas Southwestern Medical Center in Dallas, created a patient-driven computer software program -- CancerGene Connect -- that is changing the service delivery model for genetic risk assessment.

"It is an online patient-driven program that allows a patient to complete his or her family and medical history online prior to the medical appointment," Euhus said in a statement.

In 1998, Euhus created CancerGene software that includes multiple risk-assessment models that genetics professionals use to determine a patient's risk for hereditary cancers. For the first time, healthcare professionals freely could access risk assessment models on one easy-to-navigate computer program, Euhus said.

The desktop program is now used by more than 4,000 professionals in 75 countries and is updated regularly, he said

"We have taken this program to a new level and created a virtual genetic counseling environment," Euhus says. "We have found that by allowing patients to enter their family history at home, they obtain a more accurate history because they have a chance to contact their family members with questions.

"The point is to eliminate any need for survivorship because the disease itself, with the help of genetics screening and intervention, will be stopped before it begins."

Source: http://www.upi.com/Health_News/2013/06/30/Cancer-risk-determined-via-detailed-patient-histories/UPI-95531372627871/

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Samsung dominates the iPhone when it comes to phone subsidies

Samsung have done quite well for themselves over the last couple of years, fighting against the near-invincible iPhone. How does it compare to Apple in regards to phone subsidies, something Apple usually have the most control over?

?

?

Samsung are actually out and ahead, according to market research firm ABI Research and their latest report. They've said that the average implied carrier subsidy for a Samsung smartphone in the US is around 84%. What this means is that phone carriers cover 84% of the up-front costs of a Samsung phone when a consumer buys one on a contract.

?

The carrier then makes the money back on the two-year contract you've just signed through various fees and monthly charges. HTC see a subsidy of around 80%, with the iPhone sitting at 74%. ABI analyst, Stuart Carlaw, says: "Samsung continues to squeeze its competitors at every turn. The Samsung [Galaxy S4] is now considered on a par with Apple's iPhone 5. Coupled with better subsidy, the breadth of its device portfolio, increasingly savvy marketing, and its excellence in channel execution, it is little wonder Samsung is dominating the mobile handset market from top to bottom."

Source: http://www.tweaktown.com/news/31462/samsung-dominates-the-iphone-when-it-comes-to-phone-subsidies/index.html

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Egypt prepares for worst ahead of Sunday protest

CAIRO (AP) ? As the streets once again fill with protesters eager to oust the president and Islamists determined to keep him in power, Egyptians are preparing for the worst: days or weeks of urban chaos that could turn their neighborhoods into battlegrounds.

Households already beset by power cuts, fuel shortages and rising prices are stocking up on goods in case the demonstrations drag on. Businesses near protest sites are closing until crowds subside. Fences, barricades and walls are going up near homes and key buildings. And local communities are organizing citizen patrols in case security breaks down.

For yet another time since President Mohammed Morsi took office last year, his palace in Cairo's upscale Heliopolis neighborhood is set to become the focus for popular frustration with his rule. Some protests outside the capital have already turned deadly, and weapons ? including firearms ? have been circulating more openly than in the past.

"We're worried like all Egyptians that a huge crowd will come, and it will get bloody," said Magdy Ezz, owner of a menswear shop across from the walled complex, a blend of Middle Eastern and neoclassical architecture. Besides ordinary roll-down storm shutters, storefronts on the street are sealed off with steel panels.

"We just hope it will be peaceful. But it could be a second revolution," he said. "If it lasts, we'll have to keep the store closed. But it's not like business has been booming here anyway, especially since the problems last year."

Last winter, the area saw some of Cairo's deadliest street violence since the 2011 uprising, with Islamists attacking a sit-in, anarchists throwing gasoline bombs, and police savagely beating protesters.

Morsi's opponents aim to bring out massive crowds starting Sunday, saying the country is fed up with Islamist misrule that has left the economy floundering and security in shambles. They say they have collected 15 million signatures ? around 2 million more than the number of voters who elected Morsi ? calling for him to step down, and they hope the turnout will push him to do just that.

Morsi's Islamist allies say they will defend the mandate of the country's first freely elected president, some with their "souls and blood" if necessary, while hard-liners have vowed to "smash" the protests.

On Friday, thousands of Morsi supporters launched a counterdemonstration, which some plan to continue as an open-ended sit-in at a mosque near the presidential palace ? the endpoint of the main protest march two days later.

Both camps say they intend to be peaceful, but demonstrations could rapidly descend into violence ? especially if the two sides meet. Morsi's Muslim Brotherhood group has said five of its members were killed in clashes with protesters in Nile Delta provinces over the past days. On Friday, two people were killed in clashes in the port city of Alexandria and at least five Brotherhood offices were torched, while the nation's highest religious authority, Al-Azhar, warned against "civil war."

At the Brotherhood's national headquarters in Cairo's Muqattam district, workers added a final layer of mortar to a brick wall topped with grating to reinforce the main gate. A bank on the corner was completely boarded up. Some fear protesters could descend on the neighborhood to attack the headquarters, as happened last spring when supporters and opponents of the president fought street battles that left 200 wounded.

"The police have to get this place secured. It's their job and I'm sure they will," said Hadi Saad, a designer who lives around the corner from the headquarters. "The demonstrations will be very big across the country, no matter if (Morsi) stays or goes, so we should be prepared here as well."

Other neighbors said they don't expect a repeat of violence in the area, a hill overlooking the rest of the city. Only a handful of police patrolled the neighborhood ahead of the weekend protests, corralling a 100-car queue to the main avenue's gas station.

Engineer Hasan Farag, also a neighbor, said residents were "hoping for the best." Some have begun to resent the Brotherhood's presence, however, and a petition to force the offices out has been circulating.

"The neighborhood is divided ? some don't mind the headquarters being here, others do," Saad said.

Security has been redoubled at the presidential palace in Heliopolis. Walls set up last year still block some traffic access, and curved concrete slabs designed to prevent climbing now protect the main gates. Shipping containers also line much of the perimeter, and nearby apartment buildings have blocked off their parking lots and side streets with barbed wire. On Friday, authorities built a new wall of concrete blocks to surround the complex.

Peter Soliman, a communications student who lives in the neighborhood, said most residents don't know what to expect.

"Of course, parents are worried about their children going out to demonstrate by the palace, especially if the Brotherhood shows up," he said. "People fear things will turn bloody and divide the country."

Other Heliopolis residents and protest organizers say neighborhood watch groups are already being formed.

In the city center, concrete walls continue to block off the Interior Ministry and southern access routes to Tahrir Square, epicenter of the uprising that overthrew longtime autocrat Hosni Mubarak. Protesters began gathering at the square ahead of the weekend, saying they plan to dig in for a protracted conflict.

The nearby Semiramis Hotel is taking no chances, even though Tahrir is expected to be a sideshow compared to Sunday's march to the palace. The site of repeated clashes between stone-throwing youths and riot police this past year, the luxury hotel has just finished fortifying itself with a spiked metal fence topped with razor-sharp blades.

To the south, in the leafy Garden City neighborhood ? an area that has sometimes seen spillover violence from Tahrir ? some residents were securing their homes.

Metalworker Sameh Haddad used an arc welder to put the final touches on an apartment building's new wrought iron gate before hurrying to other appointments. "For once, business has been great," he said.

Source: http://news.yahoo.com/egypt-prepares-worst-ahead-sunday-protest-074010870.html

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Military Bowl great send-off for area stars

Saturday, June 29, 2013 10:54 PM EDT

EAST HARTFORD ? For six of our area?s athletes, Saturday?s Hall of Fame Classic Military Bowl was more than just another football game, it was a last hurrah for playing football at the high school level, and a great way to cap off their stellar senior seasons.

Southington?s Nick Spitz and Nathan Bonenfant, Newington?s Zachery Hedberg, Berlin?s Kevin Main and Mitch Blanchette, and New Britain?s Daequone Clark all were selected to the 2013 Senior High School All-Star football game, and though not all of them got the opportunity to make the big plays, each of them enjoyed the opportunity to be apart of the prestigious game.

?It?s a once in a life time thing,? Hedberg said. ?I?m going off to Western, so it?s a good way to end senior year.?

The National Guard and Marines held a draft to select the teams, picking from the best high school seniors the state has to offer. Whether it was the luck of the draw, or by design, both the Southington players wound up on the Marines team, while both Berlin players were chosen to the National Guard. While it won?t be the last time Main and Blanchette play on the same team, as both are committed to go to Western Connecticut State University in the fall, they still enjoyed being able to play together one more time.

?I had a lot of fun it was a good time,? Blanchette said. ?It was a great honor to have us two here to represent our town. Hector Rodriguez was supposed to be here with us but he got injured unfortunately, but we had a lot of support here today so it makes us proud that we can represent the town and pull out the win.?

?Kevin and I have been best friends since we were little so we?re excited that we get to play four more years together at Western,? Blanchette said.

Rentschler Field was the site of the Berlin Redcoats Class M State Finals defeat to Hillhouse, so playing one more time here brings up some memories for Main and Blanchette. Fortunately, for them they were chosen by the National Guard, who won the game 15-14, so Main and Blanchette get some Rentschler Field redemption.

?It was pretty emotional coming back here,? Main said. ?It was a tough loss here back in the fall, so it?s nice to leave this place with a win.?

The Southington duo of Spitz and Bonenfont won?t get the chance to play together at the next level, as Spitz will attend Salve Regina University, while Bonenfant will be playing for the Southwestern Connecticut Grizzlies prep football program, but both relished the opportunity to play together one final time.

?It was an honor to play in this game with some of the top players in the state, I?ve been waiting for months to get out here,? Bonenfant said. ?Spitz is my boy, we?ve been playing together for a long time, so it?s sad to have played in our final game together, but he?s a great player so I?m sure I?ll see him at college.?

The lone New Britain representative, Clark, didn?t receive a lot of attention during the game, he was only thrown to a couple times, but did have a big 12-yard catch to give his team the first down. While he would have liked to get some more action, it was all about the honor of being selected to the game.

?It was a good game and it was great to get out here and represent New Britain,? Clark said. ?I didn?t really get a lot of catches, but it was still fun to be apart of the game it was a great experience.?

Though Hedberg was, like Clark, the only representative from his school, his coach Roy Roberts was with him on the sidelines serving as an assistant coach for the Marines team. Though the outcome wasn?t one either Hedberg or Roberts liked, they still enjoyed their final game together,

?Coach Roberts is a very good coach,? Hedberg said. ?He loves his kids and he?s done a great job developing my brother Jake, so good luck down the road to them.?

For all the players involved, Saturday?s game was the culmination of four years of hard work. Each of them earned their spot in this game, and did their city proud with their performance.

Chris McLaughlin can be reached at (860) 225-4601 ext 255 or at cmclaughlin@newbritainherald.com

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Source: http://bristolpress.com/articles/2013/06/30/sports/doc51cf9d96d1efa635287093.txt

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Indiana University In the High School Diploma Business

Indiana University is in the business of giving out high school diplomas. Check it out! How are the students doing?
Indiana University High School graduates have gone on to dozens of prestigious colleges and universities. However, please note that earning an Indiana University High School diploma doesn't guarantee admission to Indiana University or other universities and colleges.
All parents should read this one.

Source: http://feedproxy.google.com/~r/blogspot/wHtV/~3/OvltH5I-b84/indiana-university-in-high-school.html

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It's Almost Worth Breaking Your Arm for this Crazy 3D-Printed Cast

It's Almost Worth Breaking Your Arm for this Crazy 3D-Printed Cast

Plaster casts are bulky, obnoxious, heavy, inevitably sweaty, occasionally pink. In short, they are no fun. But this 3D-printed "Cortex" cast could change all that. Sure, it looks a little like a fishnet stocking, but have you seen a old-fashioned cast lately?

A conceptual project designed by a Victoria University of Wellington graduate with the suspiciously awesome name Jake Evill, the Cortex cast is lightweight, ventilated, washable and thin thanks to its polyamide skeleton. But the bonuses aren't all for the wearer; the material of Cortex casts could be reused, unlike plaster.

It's just a concept and prototype for now, but ideally, computer software would be fed x-rays of the break and 3D scans of the limb, and design an appropriate cast shape for fixing it up, with the cast's densest parts concentrated around the actual break. The cast could then be printed out in pieces and assembled around the break with permanent fasteners. When all is said and done, it'd still have to be sawed off as usual.

Then there's the matter of time. Evill explains it this way:

At the moment, 3D printing of the cast takes around three hours whereas a plaster cast is three to nine minutes, but requires 24-72 hours to be fully set. With the improvement of 3D printing, we could see a big reduction in the time it takes to print in the future.

It sounds pretty good, but I'm seeing just one problem. How are you supposed write hideous signatures in Sharpie on surfaces that skinny? [Jake Evill via Dezeen]

Source: http://gizmodo.com/its-almost-worth-breaking-your-arm-for-this-crazy-3d-618059549

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Report: U.S. taps half-billion German phone, Internet links in month

BERLIN (Reuters) - The United States taps half a billion phone calls, emails and text messages in Germany in a typical month and has classed its biggest European ally as a target similar to China, according to secret U.S. documents quoted by a German newsmagazine.

The revelations of alleged U.S. surveillance programs based on documents taken by fugitive former National Security Agency contractor Edward Snowden have raised a political furor in the United States and abroad over the balance between privacy rights and national security.

Exposing the latest details in a string of reputed spying programs, Der Spiegel quoted from an internal NSA document which it said its reporters had seen.

The document Spiegel cited showed that the United States categorized Germany as a "third-class" partner and that surveillance there was stronger than in any other EU country, similar in extent to China, Iraq or Saudi-Arabia.

"We can attack the signals of most foreign third-class partners, and we do it too," Der Spiegel quoted a passage in the NSA document as saying.

It said the document showed that the NSA monitored phone calls, text messages, emails and internet chat contributions and has saved the metadata - that is, the connections, not the content - at its headquarters.

On an average day, the NSA monitored about 20 million German phone connections and 10 million internet data sets, rising to 60 million phone connections on busy days, the report said.

While it had been known from disclosures by Snowden that the United States tapped data in Germany, the extent was previously unclear.

News of the U.S. cyber-espionage program Prism and the British equivalent Tempora have outraged Germans, who are highly sensitive to government monitoring having lived through the Stasi secret police in the former communist East Germany and with lingering memories of the Gestapo of Hitler's Nazi regime.

A Spiegel report on Saturday that the NSA had spied on European Union offices caused outrage among EU policymakers, with some even calling for a suspension to talks for a free trade agreement between Washington and the EU.

In France, Der Spiegel reported, the United States taps about 2 million connection data a day. Only Canada, Australia, Britain and New Zealand were explicitly exempted from spy attacks.

Snowden, a U.S. citizen, fled the United States to Hong Kong in May, a few weeks before the publication in the Guardian and the Washington Post of details he provided about secret U.S. government surveillance of internet and phone traffic.

He has been holed up in a Moscow airport transit area for a week after U.S. authorities revoked his passport. The leftist government of Ecuador is reviewing his request for asylum.

(Reporting by Annika Breidthardt; Editing by Mark Heinrich)

Source: http://news.yahoo.com/u-taps-half-billion-german-phone-internet-links-093938180.html

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Trapped in Transit: Orwellian Moscow airport hotel

SHEREMETYEVO AIRPORT (AP) ? "An interesting route, Mr. Phillips," says the airport transit desk employee. "This activity makes for suspicion."

It was the start of an Orwellian adventure in which I deliberately got myself sequestered in the hopes of finding Edward Snowden at Moscow's main airport.

The experience leaves me feeling that if the NSA leaker is indeed in the transit zone of the airport, as President Vladimir Putin claims, he may already have a taste of what it's like to be in prison.

Snowden is possibly holed up in the wing of an airport hotel reserved for travelers in transit who don't have visas to enter Russia. The Novotel's main building, located outside the airport, has a plush lobby with a fountain, a trendy bar and luxury shops. One wing, however, lies within the airport's transit zone ? a kind of international limbo that is not officially Russian territory.

And that's where Snowden, whose U.S. passport has been revoked, may be hiding.

___

EDITOR'S NOTE: Eastern Europe News Director Ian Phillips flew from his home base of Prague in the Czech Republic to Moscow's Sheremetyevo Airport with the goal of getting to the bottom of the mystery of fugitive NSA leaker Edward Snowden. What followed was a surreal 21 hours.

___

The woman at the transit desk raises an eyebrow and stares at my flight itinerary, which includes a 21-hour layover in Moscow before a connection to Ukraine. "Why would ANYONE stay here in transit for so long? There are so many earlier connections you could have taken. This is strange behavior."

After a nearly two-hour wait inside the terminal, a bus picks me up ? only me ? from the transit area. We drive slowly across the tarmac, through a barrier, past electronic gates covered in barbed wire and security cameras.

The main part of the Novotel is out of bounds. My allotted wing feels like a lockup: You are obliged to stay in your room, except for brief walks along the corridor. Three cameras track your movements along the hallway and beam the images back to a multiscreen monitor. It's comforting to see a sign instructing me that, in case of an emergency, the locks on heavily fortified doors leading to the elevators will open.

When I try to leave my room, the guard outside springs to his feet. I ask him why room service isn't responding and if there's any other way to get food. He growls: "Extension 70!" I rile him by asking about the Wi-Fi, which isn't working: "Extension 75!" he snarls.

"Don't worry, Mr. Phillips," the transit desk employee had said. "We have all your details and information. We will come and get you from your room at 6 p.m. on Friday, one hour before your connecting flight."

Now it's midnight, and I'm getting edgy. I feel trapped inside my airless room, whose double windows are tightly sealed. And the room is extortionate: It costs $300 a night, with a surcharge of 50 percent slapped on because I will be staying past noon.

("Can't I just wait in the lobby after midday?" I asked the receptionist at check-in. "Of course not," she retorted. "You have no visa. You will stay until you are picked up.")

I look out the window. If Snowden is here and has the same view, he can see the approach to the departures terminal at the airport. A large billboard shows a red 4x4 vehicle driving along an ocean road. A parking lot below is filled with vehicles. A man in green overalls is watering a patch of parched grass. Vehicles whizz in and out of the airport.

A maid has just brought a tea bag. She puts a tick against the room number on the three-page document on her trolley. On it, there are no guest names, only numbers ? and departure dates. A quick look suggests there are perhaps a few dozen people staying here. A couple of rooms on my floor have tell-tale signs of occupancy ? food trays lying outside from the night before.

But no sign of Snowden.

The guard allows me to stretch my legs in the corridor. The signs on the wall rub things in. Under a pretty picture of the Moscow skyline and Red Square, a message reads: "Should you wish to see the full range of facilities offered by our hotel during your next stay, we strongly recommend you to get a visa before flying to Moscow."

A fleeting glimpse of a possible change of scene: a set of guidelines posted on the wall say I can go out for a smoke!

Rule No. 6: "It is possible to go and smoke one time per hour for 5 minutes in the beginning of each hour escorted by security service."

I don't smoke, but this would be a way to escape this floor. But when I ask him to take me down, the security guard scoffs. "No!" he says flatly.

I call the front desk. "You need a visa to go outside and smoke, Mr. Phillips" the receptionist says.

If he's here, Snowden has access to a few international TV stations. He also has a fair amount of options with room service ? the only source of food in this wing. But after almost a week, he might be getting bored. And he'd need a credit card or a lot of Russian cash. A selection:

Buffalo mozzarella and pesto dressing starter? 720 rubles (about $20).

Ribeye steak: 1,500 rubles (about $50).

Bottle of Brunello di Montalcino red wine: 5,280 rubles ($165).

A miniature bottle of Hennessy XO cognac: 2,420 rubles ($80).

I've called all the 37 rooms on my floor in hopes of reaching Snowden. No reply except for when I get my security guard.

The floor above? A similarly futile attempt.

I only reach a handful of tired and irritated Russians who growl "Da? Da? Da?" ? "Yes? Yes? Yes?"

Source: http://news.yahoo.com/trapped-transit-orwellian-moscow-airport-hotel-152338275.html

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Singapore to Indonesia: Stop sending us your smog.

Air pollution in Singapore?rose to unhealthy levels this week because of illegal forest clearing in Indonesia,?prompting?Singapore?to urge Indonesia to do something to end the haze.

By Sara Schonhardt,?Correspondent / June 20, 2013

A masked man walks as the sun sets among buildings covered with haze at the Singapore Central Business District Thursday, June 20, 2013. Singapore urged people to remain indoors amid unprecedented levels of air pollution Thursday as a smoky haze wrought by forest fires in neighboring Indonesia worsened dramatically.

Joseph Nair/AP

Enlarge

Cloudy skies in Jakarta were no match for the breathtaking haze that hit Singapore?on Thursday?as air-pollution levels rose to record highs and sparked a war of words between diplomats in both countries over who should shoulder the blame.

Skip to next paragraph Sara Schonhardt

Indonesia Correspondent

Sara Schonhardt is a Monitor contributor based in Jakarta, Indonesia, where she has been reporting since 2009.?Sara previously worked for various media in Thailand and Cambodia and received her master?s degree from the School of International and Public Affairs at Columbia University.

Recent posts

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Companies have asked employees to work from home, the military has stopped training outdoors, and pictures of Singapore's iconic Marine Bay Sands towers barely visible through the haze have been splashed across social media platforms?and newspapers.

Despite the international blame game, the immediate cause was clear enough: fires used to clear land in Sumatra for farming and palm oil plantations. A local meteorological agency reported nearly 150 hotspots alone in Riau Province, itself a hotspot for mining, logging, and palm oil production.

Environmental advocacy group Greenpeace released a statement saying that the fires illustrated how Indonesia?s government policies aimed at reducing deforestation had failed?since half of them were in areas off-limits to land clearing.

Each year slash and burn practices in Indonesia shroud neighboring Singapore and Malaysia in thick haze. As deforestation has accelerated in recent years, it has worsened.

On Thursday,?Singapore sent a delegation from its environmental agency to Jakarta to call for immediate action.?Singapore?s environment minister, Vivian Balakrishnan, issued an angry statement?on his Facebook page saying no country or corporation ?has the right to pollute the air at the expense of Singaporeans? health and well-being.??

But Indonesia shot back its own statement: Singapore should stop ?behaving like a child,? said Indonesia?s?Coordinating Minister for People's Welfare, Agung Laksono, who oversees fire response.

Mr. Balakrishnan had asked the Indonesian government to name and shame the companies involved in the illegal burning. But Indonesia?s forestry ministry launched back, saying?Singapore and Malaysia shared the responsibility for putting pressure on the resource extraction industry since many of companies were based in their countries.

Source: http://rss.csmonitor.com/~r/csmonitor/globalnews/~3/DSOCJEKKLvY/Singapore-to-Indonesia-Stop-sending-us-your-smog

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Scientists view 'protein origami' to help understand, prevent certain diseases

June 28, 2013 ? Scientists using sophisticated imaging techniques have observed a molecular protein folding process that may help medical researchers understand and treat diseases such as Alzheimer's, Lou Gehrig's and cancer.

The study, reported this month in the journal Cell, verifies a process that scientists knew existed but with a mechanism they had never been able to observe, according to Dr. Hays Rye, Texas A&M AgriLife Research biochemist.

"This is a step in the direction of understanding how to modulate systems to prevent diseases like Alzheimer's. We needed to understand the cell's folding machines and how they interact with each other in a complicated network," said Rye, who also is associate professor of biochemistry and biophysics at Texas A&M.

Rye explained that individual amino acids get linked together like beads on a string as a protein is made in the cell.

"But that linear sequence of amino acids is not functional," he explained. "It's like an origami structure that has to fold up into a three-dimensional shape to do what it has to do."

Rye said researchers have been trying to understand this process for more than 50 years, but in a living cell the process is complicated by the presence of many proteins in a concentrated environment.

"The constraints on getting that protein to fold up into a good 'origami' structure are a lot more demanding," he said. "So, there are special protein machines, known as molecular chaperones, in the cell that help proteins fold."

But how the molecular chaperones help protein fold when it isn't folding well by itself has been the nagging question for researchers.

"Molecular chaperones are like little machines, because they have levers and gears and power sources. They go through turning over cycles and just sort of buzz along inside a cell, driving a protein folding reaction every few seconds," Rye said.

The many chemical reactions that are essential to life rely on the exact three-dimensional shape of folded proteins, he said. In the cell, enzymes, for example, are specialized proteins that help speed biological processes along by binding molecules and bringing them together in just the right way.

"They are bound together like a three-dimensional jigsaw puzzle," Rye explained. "And the proteins -- those little beads on the string that are designed to fold up like origami -- are folded to position all these beads in three-dimensional space to perfectly wrap around those molecules and do those chemical reactions.

"If that doesn't happen -- if the protein doesn't get folded up right -- the chemical reaction can't be done. And if it's essential, the cell dies because it can't convert food into power needed to build the other structures in the cell that are needed. Chemical reactions are the structural underpinning of how cells are put together, and all of that depends on the proteins being folded in the right way."

When a protein doesn't fold or folds incorrectly it turns into an "aggregate," which Rye described as "white goo that looks kind of like a mayonnaise, like crud in the test tube.

"You're dead; the cell dies," he said.

Over the past 20 years, he said, researchers have linked that aggregation process "pretty convincingly" to the development of diseases -- Alzheimer's disease, Lou Gehrig's disease, Huntington's disease, to name a few. There's evidence that diabetes and cancer also are linked to protein folding disorders.

"One of the main roles for the molecular chaperones is preventing those protein misfolding events that lead to aggregation and not letting a cell get poisoned by badly folded or aggregated proteins," he said.

Rye's team focused on a key molecular chaperone -- the HSP60.

"They're called HSP for 'heat shock protein' because when the cell is stressed with heat, the proteins get unstable and start to fall apart and unfold," Rye said. "The cell is built to respond by making more of the chaperones to try and fix the problem.

"This particular chaperone takes unfolded protein and goes through a chemical reaction to bind the unfolded protein and literally puts it inside a little 'box,'" Rye said.

He added that the mystery had long been how the folding worked because, while researchers could see evidence of that happening, no one had ever seen precisely how it happened.

Rye and the team zeroed in on a chemically modified mutant that in other experiments had seemed to stall at an important step in the process that the "machine" goes through to start the folding action. This clued the researchers that this stalling might make it easier to watch.

They then used cryo-electron microscopy to capture hundreds of thousands of images of the process at very high resolutions which allowed them to reconstruct from two-dimensional flat images a three-dimensional model. A highly sophisticated computer algorithm aligns the images and classifies them in subcategories.

"If you have enough of them you can actually reconstruct and view a structure as a three-dimensional model," Rye said.

What the team saw was this: The HSP60 chaperone is designed to recognize proteins that are not folded from the ones that are. It binds them and then has a separate co-chaperone that puts a "lid" on top of the box to keep the folding intermediate in the box. They could see the box move, and parts of the molecule moved to peel the chaperone box away from the bound protein -- or "gift" in the box. But the bound protein was kept inside the package where it could then initiate a folding reaction. They saw tiny tentacles, "like a little octopus in the bottom of the box rising up and grabbing hold of the substrate protein and helping hold it inside the cavity."

"The first thing we saw was a large amount of an unfolded protein inside of this cavity," he said. "Even though we knew from lots and lots of other studies that it had to go in there, nobody had ever seen it like this before. We can also see the non-native protein interacting with parts of the box that no one had ever seen before. It was exciting to see all of this for the first time. I think we got a glimpse of a protein in the process of folding, which we actually can compare to other structures."

"By understanding the mechanism of these machines, the hope is that one of the things we can learn to do is turn them up or turn them off when we need to, like for a patient who has one of the protein folding diseases," he said.

Rye collaborated on the research with Dong-Hua Chen and Wah Chiu at the Baylor College of Medicine in Houston, Damian Madan and Zohn Lin at Princeton University, Jeremy Weaver at Texas A&M and Gunnar Schr?der at the Institute of Complex Systems in Germany.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/PfjFPU7j0xE/130628120759.htm

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Saturday, June 29, 2013

Cammy's Covers - Hawkeye To Elephantmen - Bleeding Cool ...

hawkeye11Cameron Hatheway writes;

Hawkeye #11 by David Aja

Now either this dog is a stone-blooded killer, or he just accidentally walked through some raspberry jam. Having a Labrador myself, I would not be surprised whatsoever if it was explanation number two. Again with Aja, it?s the simple things that really speak volumes when illustrating a cover with little detail as possible. Bottom line, this cover is doggone good!

amalasblade3Amala?s Blade #3 by Michael Dialynas

And that?s why you always make sure the back gate is locked. Heaven forbid if your beloved cybernetic serpent hound gets out and runs away. I initially thought this was a Paul Pope cover, but alas it?s not. Michael Dialynas does a superb job here with the grittiness and the coloring, for there?s tons of energy in this cover. I can hear the snarls of hell from just staring at it.

prophet36Prophet #36 by Aaron Conley

This illustration must be a postcard from planet Australia, because it appears that everything on this cover is trying to kill you. The yellow and green starfish (or in this case, murderfish) combined with the gem throne and see-through goldfish at the bottom balance perfectly, for it feels good to allow the eyes to wander. Lots of great stuff happening here, or as the Prophets call it, ?Just another day.?

bprdvampire4B.P.R.D.: Vampire #4 by F?bio Moon

The thing I love the most about this cover is you don?t see the head or body of the spider, but merely the legs emerging from the dark. It could look like a thousand different things, but because we?re relying on our own references, it?s going to end up being a manifestation of our worst nightmares. It?s big, it?s creepy as hell, and while you?re reading this article, it?s slowly dangling down from overhead.

theunwritten50The Unwritten #50 by Yuko Shimizu

A Fables/The Unwritten crossover? Shut up and take my money! It will be interesting (and by that I mean fascinating) to see what Shimizu has in store for us as she illustrates characters from both universes. Already I?m loving her take on Bigby, and the flowers, birds, and big cloud of smoke are a nice touch as well. Can?t wait to see what the next cover holds!

elephantment49Elephantmen #49 by Boo Cook

This is my favorite cover of the week, hands down. It doesn?t get any more science-fictiony than this! Troops on the planet?s surface fending off from crystal serpents with nasty big pointy teeth; Can this please be a movie?? Boo Cook goes above and beyond with this cover, for it?s a painted masterpiece depicting some of the coolest alien action I?ve seen in a long time. I can only imagine what the interior art looks like!

Cameron Hatheway is the host of Cammy?s Comic Corner and Arts & Entertainment Editor of the Sonoma State STAR. You can watch him devour pulled pork sliders on Twitter @CamComicCorner.

Source: http://www.bleedingcool.com/2013/06/29/cammys-covers-hawkeye-to-elephantmen/

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Obama recasts chase for Snowden as unexceptional

WASHINGTON (AP) ? The last thing President Barack Obama wants to do is turn Edward Snowden into a grand enemy of the state or a Daniel Ellsberg-type hero who speaks truth to power.

In the shifting narrative of the Obama administration, the man whose leaks of top-secret material about government surveillance programs have tied the national security apparatus in knots and brought charges under the Espionage Act has now been demoted to a common fugitive unworthy of international intrigue or extraordinary pursuit by the U.S. government.

A "29-year-old hacker," in the words of Obama; fodder for a made-for-TV movie, perhaps, but not much more.

"This is not exceptional from a legal perspective," the president said Thursday of Snowden's efforts to avoid capture by hopscotching from Hawaii to Hong Kong to Russia.

"I'm not going to have one case of a suspect who we're trying to extradite suddenly being elevated to the point where I've got to start doing wheeling and dealing and trading on a whole host of other issues simply to get a guy extradited," the president told reporters in Senegal.

It was the second time in a week that the administration had toned down its rhetoric as Snowden remained out of reach and first China and then Russia refused to send him back.

Just Monday, Secretary of State John Kerry was talking tough against China and calling Snowden a traitor whose actions are "despicable and beyond description." By Tuesday, Kerry was calling for "calm and reasonableness" on the matter, and adding, "We're not looking for a confrontation. We are not ordering anybody."

There are plenty of reasons for Obama to pull back, beyond his professed desire to avoid international horse-trading for the leaker.

The president, in his own words, has "a whole lot of business to do with China and Russia." Why increase tensions in an already uneasy relationship when Obama is looking for Russia's cooperation in finding a path to peace in Syria, for example?

In addition, less-heated dialogue could make it easier to broker Snowden's return because, despite the latest shrugs, U.S. officials very much want him.

"There's a lot of signaling going on," said Steve Aftergood, director of the Project on Government Secrecy for the Federation of American Scientists. "If the White House were issuing ultimatums, then Russia might feel obliged not to cooperate. But if it's merely one request among many others, that might make it easier to advance to a resolution."

The president also may have a U.S. audience in mind for his comments.

Obama's Democratic base includes plenty of defenders of civil liberties who are sympathetic to Snowden's professed goal of making government more transparent.

Benjamin Pauker, managing editor of Foreign Policy magazine, said the president was loath to elevate Snowden to a state enemy or "an Ellsberg-type truth-teller," referring to the 1971 leaker of the Pentagon Papers, which showed the U.S. government had misled the public about the war in Vietnam.

Ellsberg himself recently called Snowden's revelations the most significant disclosures in the nation's history.

The administration, though, would rather marginalize Snowden, a former National Security Agency systems analyst who is thought to have custody of more classified documents.

"Calling him a hacker, as opposed to a government contractor or an NSA employee, brings him down a notch to someone who's an irritant, as opposed to someone who has access to integral intelligence files," Pauker said. "To externalize him and brand him with a black-hat hacker tag distances him from the government."

The disdainful talk isn't just coming from the White House.

Rep. Mike Rogers, R-Mich., the chairman of the House Intelligence Committee, called Snowden "a high school dropout who had a whole series of both academic troubles and employment troubles" after a recent closed hearing on the leaks. The committee's top Democrat, C.A. "Dutch" Ruppersberger from Maryland, called Snowden "a legend in his own mind" for claiming to be able to use NSA systems to access any email or phone call anywhere ? something the NSA's director has said can't be done.

There may also be face-saving benefits for Obama in cutting down Snowden, who turned 30 last week. An unsuccessful full-court press for Snowden's return would only show the limitations of Obama's international influence.

It's not the first time a president has tried to reset expectations by first elevating and then playing down the importance of an international fugitive who eluded capture, at least for a time.

President George W. Bush went from putting out a "dead-or-alive" ultimatum for 9-11 terror mastermind Osama bin Laden to dismissing him as "a person who's now been marginalized."

"I just don't spend that much time on him," Bush said in March 2002.

Candidate Barack Obama pledged during the 2008 presidential campaign: "We will kill bin Laden, we will crush al-Qaida. That has to be our biggest national security priority."

By January 2009, just days before his inauguration, Obama was saying: "My preference, obviously would be to capture or kill him. But if we have so tightened the noose that he's in a cave somewhere and can't even communicate with his operatives, then we would meet our goal of protecting America."

As it turned out, he got him.

___

AP Intelligence Writer Kimberly Dozier contributed to this report.

___

Follow Nancy Benac on Twitter: http://www.twitter.com/nbenac

Source: http://news.yahoo.com/obama-recasts-chase-snowden-unexceptional-073112725.html

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Uh Oh: Forum Communications Confirms Missing Emails From ...

The timing of the deletion of emails from NDSU President Dean Bresciani?s inbox has always been interesting. It appears as though the mass-deletion of tens of thousands of emails took place between the time when an open records request from Forum Communicatinos was fulfilled and when an open records request from Legislative Council was received.

The folks at Forum Communications have gone back and compared the results of their open records request with the one from Legislative Council and found inconsistencies involving dozens of emails:

The newspaper compared the results of its own open records request for Bresciani?s emails, made in March, with those that the North Dakota Legislative Council received after a similar request in April and found that 53 emails were missing from the results of the council?s request.

Nearly all of the emails in the Legislative Council?s request were sent by Bresciani, with few incoming emails that would sit in an inbox, suggesting that at least part of the president?s inbox was deleted sometime after The Forum?s open records request was fulfilled in late April.

The missing emails, mostly innocuous replies to Bresciani from fellow school employees, are just a fraction of the 45,375 emails that were allegedly deleted from Bresciani?s account sometime in the two weeks leading up to the Legislative Council?s request for the president?s emails ? a possible violation of the state?s open records law. The emails are now at the heart of a probe by Attorney General Wayne Stenehjem?s office.

This in and of itself may not be all that shocking a revelation. A few dozen innocuous emails probably aren?t a big deal in the grand scheme of things. But what it absolutely shows is that emails were disappearing.

And, despite previous claims from university system officials that they couldn?t verify if emails had been deleted or not, they are now acknowledging that fact. ?After being asked about the 53 missing emails identified by the Forum, NDSU and North Dakota University System officials confirmed Friday that ?a large number of emails? have been deleted,? reports Kyle Potter. ?Bresciani and other university staff initially said they couldn?t verify whether any emails had been deleted from Bresciani?s account.?

Also, Bresciani?s claim that his system was ?compromised? has been shot down:

[Bresciani] also suggested his account may have been compromised by university system staff in a ?personally directed and malicious? effort against him. But Wallman and Feldner said in the statement that the only outsiders who accessed the president?s account were fulfilling open records requests.

Days ago I had filed an open records request with NDUS spokeswoman Linda Donlin asking for the log information showing the deletion of the files. After initially acknowledging my request I?ve gotten no further communications for Donlin (who is part of the staff upheaval going on, it seems) but a university system source has given me a screen shot of the log showing the deletion of emails:

logfile

We can now dismiss a lot of the spin and self-serving explanations coming from President Bresciani?s office and other sources and focus on some facts:

  • The emails were absolutely deleted from Bresciani?s inbox.
  • Bresciani?s inbox was not ?compromised? by anyone from the university system office, despite his wild allegations.
  • NDSU did not fully complete the legislature?s request for emails given the discrepancies between the Forum Communications request and the Legislative Council request.

The questions that need to be answered is who deleted the emails, and were they deleted inadvertently or as an conscious effort to avoid an open records request? The latter, remember, is potentially a felony.

Word I?m getting from university system sources is that there were thousands of emails now-discovered that weren?t turned over to the legislature. That, if true, is damning.

Source: http://sayanythingblog.com/entry/uh-oh-forum-communications-confirms-missing-emails-from-brescianis-inbox/

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Jobs in the Arts - Marketing & Communications Manager / BAX





Marketing & Communications Manager
BAX | Brooklyn Arts Exchange
(Brooklyn NY)

BAX/Brooklyn Arts Exchange Seeks
MARKETING & COMMUNICATIONS MANAGER
BAX/Brooklyn Arts Exchange, founded in 1991, is a community based performing arts center dedicated to developing artists of all ages, from children to professionals. The organization offers community access to arts and culture, supporting the creation of new work by emerging artists, engaging diverse audiences and providing arts education to youth and families. BAX has intentionally constructed an environment where children study and professional artists create under the same roof. Students are mentored by professional directors and choreographers. The organization?s distinct focus on developmental process makes it a nurturing incubator for experimental dance and theater artists and is an important advocate for under-represented voices in the New York City performing arts community.
The Marketing Department is comprised of the Marketing & Communications Director, Marketing & Communication Manager, part time Graphics Designer, and one-two interns and volunteers.
The Marketing & Communications Manager is integral to the smooth operation of the marketing department and acts as project manager for all organizational marketing initiatives. This position works directly with BAX?s Marketing & Communications Director communicating with audiences, artists, students and families to support the programs, events, classes and workshops at BAX.
This is a 30 hour a week year-round position.
Duties include (but are not limited to):
INTAKE, ORGANIZE AND ARCHIVE
- manage the intake and archiving of content and information regarding all organizational programs and events
- creating online forms for the intake of information
- sending out reminder communications asking for content from artists and other departments
- manage the department contact lists
- maintain the organization of departmental files
BRAINSTORM / STRATEGIZE
- support Director in creating strategies and actionable plans to promote/market the organization, its programs and events
- assist the Director in creating and monitoring department initiatives
- assist the Managing Director in maintaining the database interface
IMPLEMENTATION
- assess, implement, and monitor specific tasks necessary to manifest department goals and initiatives
- maintain the website and research new functionality
- implement the email-based marketing initiatives
- maintain the tasks and events calendar?on google
- monitor and maintain social media sites (Facebook, Twitter, Google +) and online media storage/sharing sites
DEPARTMENTAL LIAISON
- assist in managing interdepartmental communications
- assist in managing the interns/volunteers
- box office management
THE IDEAL CANDIDATE
- is highly organized and attentive to detail
- has strong ability to multi-task
- works well autonomously
- is unafraid to ask questions
- has experience with Microsoft Word, Excel, Publisher and database software
- has a basic understanding of HTML (experience with WordPress a plus)
- is experienced with various Social Media platforms
- is interested in the performing arts
- is willing and excited to learn
The work schedule will be set upon hiring. Please note that working full days on Mondays and Fridays will be required; and that while weekends are usually off, attendance will be mandatory at some weekend events.
Salary is in the low-mid 20?s with health benefits and paid vacation, personal and sick days.
Email cover letter, resume and three employment/character references to search@bax.org by JULY 26, 2013.
Cover letter should address your interest in this position, and highlight the qualifications that make you a good candidate. References should include names, titles, addresses, contact numbers and emails.
Interviews will take place July 29 - August 2. Call-backs will take place August 5 - 9.
Training will begin mid/late August.
No phone calls, please. Questions can be directed to search@bax.org.

BAX/Brooklyn Arts Exchange is located on 421 Fifth Avenue, Park Slope, Brooklyn, NY
BAX is an equal opportunity employer. To learn more about BAX, please visit www.bax.org.

Website: http://www.bax.org

Source: http://www.nyfa.org/opp_detail.asp?type=Job&id=94&fid=1&sid=54&oppid=47498

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Same-sex weddings under way in California after stay is lifted

Paul Katami and Jeff Zarrillo, one of the couples who successfully challenged California's Proposition 8, marry in Los Angeles.

By Pete Williams and M. Alex Johnson, NBC News

The two couples who challenged?the law that had?barred same-sex marriage in California?were married Friday afternoon after a federal appeals court dissolved its stay blocking same-sex marriage in the state.

On the eve of San Francisco's Pride Weekend,?State Attorney General Kamala?declared Sandra Stier, 50, and Kris Perry,?48, "spouse and spouse" shortly before 5 p.m. (8 p.m. ET) at San Francisco City Hall. In their vows, the couple took each other as?"lawfully wedded wife."


"Right now, we feel really victorious and thrilled and relieved to be at the end of this long journey and just move forward like a regular married couple," Stier said in a conference call with reporters ? but not before she introduced Perry as "my beautiful wife."

Stier said she and Perry hadn't had time to schedule a honeymoon. But Perry said that after a celebration with "all of the people we love ... Sandy and I will go somewhere alone."

Jeff Chiu / AP

Kris Perry, left, kisses Sandra Stier as they are married Friday at San Francisco City Hall in a ceremony officiated by state Attorney General Kamala Harris.

?

About 90 minutes later in Los Angeles, Mayor Antonio Villaraigosa married the other couple, Paul Katami and Jeff Zarrillo, on his last day in office.?

The ceremony, Katami said, was "about celebrating our private commitment and our public connection."

Many state officials, including Harris and Gov. Jerry Brown, celebrated the decision Friday on Twitter:

Twitter.com

Twitter.com

San Francisco City Hall will stay open until 8 p.m. Friday and will be open 9 a.m. to 5 p.m. Saturday and Sunday for marriage licenses. The Los Angeles County registrar and clerk's office said it was deputizing extra marriage commissioners and extending days and locations to accommodate an expected rush of weddings.

Gina Alcomendias, the clerk-recorder for Santa Clara County, said few people had shown up at the County Building because the appeals court's decision came late in the day.

But "we're going to be busy Monday, I think ? the whole week next week," Alcomendias told NBC Bay Area. "Probably for a long while."

The 9th Circuit U.S. Court of Appeals lifted its stay two days after the Supreme Court declined to rule on Proposition 8, thereby upholding a lower court's decision overturning the ban.?The appeals court had blocked enforcement of that ruling pending the Supreme Court decision.

The justices also struck down?the Defense of Marriage Act, a 1996 federal law that barred recognition of same-sex marriages.

Supreme Court rulings generally don't take effect for 25 days. But Harris had called on the 9th Circuit to lift its stay as soon as possible Wednesday after Brown told the state's 58 counties to prepare for same-sex marriages.

Brown issued an order Friday afternoon making that official, declaring that "marriage licenses must be issued to same-sex couples immediately."

California Attorney General Kamala Harris instructs the Los Angeles County Clerk by telephone to begin same-sex marriages "immediately."

The Protect Marriage Coalition's?Proposition 8 Legal Defense Fund, which sponsored the ballot initiative, did not immediately return calls seeking comment. But in a statement, the group said it had been deprived of "our right to ask for reconsideration," calling the appeals court's decision an "outrageous act of judicial tyranny."

"Homosexual marriage is not happening because the people changed their mind," the group said in a statement. "It isn't happening because the appellate courts declared a new constitutional right. It's happening because enemies of the people have abused their power to manipulate the system and render the people voiceless."

Theodore Boutros, one of the plaintiffs' lawyers, said the appeals court was fully within its rights to lift its injunction, which simply restored the status quo in the circuit. Any attempt by opponents to seek reconsideration of the Supreme Court ruling is a separate matter, he said.

Watch the most-viewed videos on NBCNews.com

Miranda Leitsinger, Norma Rubio and Sossy Dombourian of NBC News contributed to this report. Follow M. Alex Johnson on Twitter and Facebook.

Related:

Same-sex marriage supporters cheer 'Cinderella moment'; opponents vow to fight on

Historic day for gay marriage after two big court decisions

This story was originally published on

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'Lola' tops 204 mph, breaking electric vehicle land speed record

Autos

14 hours ago

Drayson Racing team members celebrate their land speed record.

Drayson Racing/The Detroit Bureau

Drayson Racing team members celebrate their land speed record.

With all the emphasis on electric propulsion these days, it might seem hard to believe that it?s been 39 years since General Electric ? yes, GE ? set the FIA World Electric Land Speed Record. But that achievement has finally been bested by a sleek, Le Mans Prototype dubbed ?Lola.?

On an RAF airbase in Yorkshire, England, an 850-horsepower battery-electric built by Drayson Racing hit a top speed of 204.185 miles per hour during a pair of runs down a 3-kilometer (nearly 2-mile) track. That was a full 29 mph faster than the 175 mph record set way back in 1974 by the Battery Box General Electric.

?I?m delighted we?ve beaten the record tonight and can show the world EVs can be fast and reliable,? said Lord Paul Drayson, whose firm built the 2,200 battery, and who personally piloted it during the record run. ?It is not the outright speed of 204.185 mph that is most impressive about this record, but the engineering challenge of accelerating a 1000 kilogram electric vehicle on a short runway over a measured mile.?

Officially known as the Drayson B12 69/EV the enclosed racer used ultra-light carbon fiber for its chassis and body to compensate for the heft of a 30 kilowatt-hour battery pack. It also relied on custom-designed Michelin LM P1 tires.

Though most folks likely associate electric propulsion with ? but slow ? vehicles like the Nissan Leaf or Chevrolet Volt, the reality is that battery power can also deliver some impressive performance as an electric motor yields maximum torque the moment it starts spinning.

Drayson?s Lola can launch from 0 to 60 in less than 4 seconds, for example, and keep gaining speed until it?s pushed well past 200 mph. In fact, Lord Drayson is apparently looking to soon beat his own record, tweeting to fans that on an additional run the car was ?very lively at 216 mph.?

While he may be celebrating victory, the claimed record could come under dispute. The Buckeye Bullet, an EV built by students at Ohio State University, actually achieved a 307.7 mph average during two runs at the Bonneville Salt Flats in Utah in August 2010 ? and was seen as capable of reaching 400 mph. But that effort was not officially sanctioned by the FIA, leaving GE?s Battery Box the certified record-holder for another three years.

To proponents, what matters most is the increasing focus in electric racing and battery propulsion, in general.

There?s clearly a lot more interest, for example, has nudged its ZEOD RC battery race car up to 186 mph, and Top EV Racing claims to have launched its battery dragster from 0 to 100 in a mind-boggling 0.8 seconds.

What could put battery racing square in the public eye is the new Formula E series set to launch in 2015. Not surprisingly, Lord Drayson is looking to participate when that program gets underway.

Copyright ? 2009-2013, The Detroit Bureau

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Combo Crew (for Android)


Combo Crew, the latest Android title from developer The Game Bakers, aims to eliminate one of the problems inherent to mobile action games: poor touch screen controls. Instead of requiring gamers to continuously jam their digits onto a glass screen, Combo Crew maps punches, kicks, and super moves to swipes?a far superior way to interact with a touchscreen interface. While it's easy to unleash moves in this arena-style 2D brawler, design elements intended to streamline the controls remove the challenge and the need for move set mastery.

Welcome to the Jungle
Combo Crew opens with a generic backstory that plays out as a pseudo-parody of games of this type: Mr. Boss invites Gina (a Hair-Fu practitioner), Dolph (an action movie star), and Parker (a video game junkie) to his Boss Tower for dinner?but it's a trap! The baddie simply wants to challenge and defeat the best fighters in order to stroke his ego.

Although Combo Crew introduces you to three cutesy protagonists, only Gina and Parker are available for fisticuffs duty right away; you unlock Dolph after you've fought a few matches and earned 20 in-game credits (that's right, in-game currency?no cash needed). A fourth character, Sammo, is also a 20-credit buy.

Each brawler starts with four attacks?a mix of regular blows, guard breakers, and crow ground attacks. New moves are unlocked as you complete chapters, while other moves are unlocked after successfully completing missions in Combo Crew mode (a series of fight-based challenges). Once new moves are acquired, you can use them to replace the old ones if you'd like, but you can only carry four attacks at a time. Spending credits in the Shop lets you purchase Boosts (temporary power-ups such as a health-replenishing burger) or Perks (permanent character improvements such as a greater damage output).

Fight Club
Swipe-based inputs are how you unleash your fury onto Mr. Boss' foot soldiers. Swiping up, down, left, or right executes basic attacks, but there are advanced methods, too. Tapping the screen, holding, and then swiping toward an enemy delivers a guard breaker that crumbles a block defense. Swiping with two fingers uncorks impressive auto-combos that string multiple hits together without any further input. When your super-meter is full, tapping the super-attack icon lets you bust out a flurry of hard-hitting moves. There's a surprisingly amount of depth to the combat system: you can even do air juggles and knockdown attacks. Your combos are tallied as you land blows, and the music gets remixed on the fly as the total grows.

The simplified combat works well and the hits are quite satisfying, but there are some associated tradeoffs. You don't actually move your opponent; swiping causes your character to dash toward a foe and attack. You can't rely on positioning to set up attacks/dodges as you can with classic beat 'em ups like Double Dragon or River City Ransom. If you want to avoid an attack, you must swipe attack when an exclamation point appears over an enemy's head to perform a counter. The streamlined controls also result in button-mashing as a viable combat scheme, which removes the challenge.

Combo Crew is a solo experience, but there is an unusual (and creative) asynchronous co-op element. Suppose a bad guy gives you the business and whittles your health down to zero. Instead enduring a game over, you can ask a Combo Crew-playing friend to remotely take over your game. Your buddy has the opportunity to finish up your mess, and if s/he beats the round, your friend's score is converted into health for your character. When your fighter's health gauge is filled, any remaining points are added to your score.

Knuckle Up
Combo Crew is an entertaining diversion that should scratch genre fans' beat 'em up itch. It's cute, colorful, and had a surprisingly deep combat system. Still, you don't necessarily need to learn it; button-mashing can get the job done, too. What makes Combo Crew work, the simple control scheme, also works against it. Still, those who want to punch a few grunts in the face will find a lot to like.

Source: http://feedproxy.google.com/~r/ziffdavis/pcmag/~3/ctQKZOPkw8o/0,2817,2421192,00.asp

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Catch 'Man of Steel' and 'Pulp Fiction' at The Oaks - Entertainment ...

Here is a list of movies playing at the Oaks Theater in Oakmont from Friday, June 20, to Thursday, July 4. The theater is at 310 Allegheny River Blvd. For more information, call 412-828-6322.

The cost is $8 general admission after 6 p.m. Matinees cost $6. General admission for senior citizens, students and youths is $6.

Man of Steel (2013)

June 28, July 1 and July 2?4 p.m. and 7 p.m.?
June 29?1 p.m. and 4 p.m.
June 30?1 p.m., 4 p.m. and 7 p.m.?
July 3?4 p.m.??

Pulp Fiction (1994)
June 28 and 29?10 p.m.?

The Rep (2013)
June 29 and July 3?7 p.m.?

Become a blogger today!
Get started now

Source: http://plum-oakmont.patch.com/groups/arts-and-entertainment/p/catch-man-of-steel-and-pulp-fiction-at-the-oaks

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Bubble tea | Food and Beverage

Boba milk tea, also known as pearl milk tea or PMT, is a Taiwanese tea-based drink invented in tea shops in Taichung, Taiwan, during the 1980s. Most bubble tea recipes contain a tea base mixed with fruit or milk. Ice-blended versions are usually mixed with fruit or syrup, resulting in a slushy consistency. Most bubble teas come with small chewy tapioca balls, commonly called ?pearls? or ?boba? .

There are many variants of the drinks, and many kinds of types are used and ingredients added. The most popular bubble drinks are bubble milk tea with tapioca and bubble milk green tea with tapioca.

Source: http://heromobilecafe.com/bubble-tea

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Microsoft Build 2013 event wrap-up

Microsoft Build 2013 event wrapup

We came. We handled Windows 8.1. We grabbed news about the latest and greatest from Microsoft. We picked up a few new Steve Ballmer catch phrases ("touch touch touch touch!"). Then, we left. In a nutshell, this was our experience covering Microsoft Build 2013 this week at the Moscone Center, though it obviously was much more involved. Fortunately, we were able to bring you, dear reader, along for the action -- but in case you missed any of the excitement as it happened, you'll find a list of all of the announcements, hands-ons and other posts we covered during the event below the break. Feel free to also visit our Build event page for an extra visual oomph.

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Source: http://www.engadget.com/2013/06/28/microsoft-build-2013-event-wrap-up/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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Egypt clerics warn of 'civil war' amid skirmishes

By Yasmine Saleh and Abdelrahman Youssef

CAIRO/ALEXANDRIA (Reuters) - Egypt's leading religious authority warned of "civil war" and appealed for calm amid scattered violence on Friday, days before mass demonstrations that the opposition hopes can force the Islamist president to quit.

One man was shot dead and dozens wounded in Alexandria when protest marchers and Islamists clashed. A member of the ruling Muslim Brotherhood was also shot dead overnight in the city of Zagazig.

Friday's demonstrations were called in advance of a day of mass marching on Sunday, when President Mohamed Mursi's critics hope millions will hit the streets to demand new elections.

"Vigilance is required to ensure we do not slide into civil war," said clerics of Cairo's thousand-year-old Al-Azhar institute, one of the most influential centers of scholarship in the Muslim world.

In a statement broadly supportive of Mursi, it urged dialogue and blamed "criminal gangs" who besieged mosques for violence which the Brotherhood said has killed at least five supporters in a week.

The Brotherhood's political wing warned of "dire consequences that will pull the country into a violent spiral of anarchy". It held liberal leaders, including former U.N. diplomat Mohamed ElBaradei, personally responsible for inciting violence by hired "thugs" once employed by the ousted dictator, Hosni Mubarak.

Opposition leaders condemned the violence. The army, which has warned it could intervene if political leaders lose control, issued a statement saying it had deployed across the country to protect citizens and installations of national importance.

An Islamist rally in Cairo included calls to reconciliation.

In Alexandria, Egypt's second city, 70 people were wounded, many by birdshot, officials said. Nine policemen were also injured after hundreds fought around a Brotherhood office.

As several thousand anti-Mursi protesters marched along the Mediterranean seafront, a Reuters reporter saw about a dozen men throw rocks at guards outside the building. They responded. Bricks and bottles flew. Gunshots went off. Eventually, the office was trashed and documents burned, watched by jubilant youths chanting against the country's Islamist leaders.

Days of political violence in Nile Delta towns between Cairo and Alexandria continued. More than 40 were wounded on Friday in two towns. Overnight, the Brotherhood said, one man was killed and four were wounded in a raid on its office in Zagazig.

CAIRO CALM

There was no trouble during the afternoon in Cairo when tens of thousands of Islamists gathered round a mosque after weekly prayers to show support for Mursi. His opponents hope millions will turn out on Sunday to demand he step down, a year to the day since he was sworn in as Egypt's first freely chosen leader.

"I came to support the legitimate order," said Ahmed al-Maghrabi, 37, a shopkeeper from the Nile Delta city of Mansoura whose hand bore grazes from street fighting there this week. "I am with the elected president. He needs to see out his term."

There was a mostly festive atmosphere in the hot sunshine.

Some speakers reflected fear among Islamists that opponents aim to suppress them as Mubarak did. But there was also talk from the podium of the need for dialogue - a concern also of international powers worried by bitter polarization.

At one point, a song was played praising unity among "Muslims and Christians, Islamists and liberals" - a marked contrast to a similar gathering in the same spot last Friday when hardliners warned opponents against attacking Mursi.

Standing above pictures of those killed, Abdel Rahman al-Barr, a Brotherhood leader, said: "The only way forward is for us to sit down together ... To those who smash a hole in the ship of state, we will not respond by smashing another. We will work to repair the hole. We will not let the ship sink."

Some opposition gatherings were also under way, though small, perhaps due to mixed messages from leaders about whether to start the "June 30" protest movement early. A handful of protesters watched security men ringing the presidential palace, the focus for Sunday's Cairo rally. Mursi has moved elsewhere.

A few thousand milled around in the capital's Tahrir Square, cradle of the revolution. Some waved red cards reading "Out!", in preparation for the big demonstration against the president.

A protest of about 3,000 in Port Said, a bastion of anti-Islamist sentiment on the Suez Canal, passed off peacefully. Shipping in the international waterway was unaffected.

STRATEGIC

The army, which heeded mass protests in early 2011 to push aside Mubarak, has warned it will intervene again if there is violence and to defend the "will of the people". Both sides believe that means the military may support their positions.

The United States, which funds Egypt's army as it did under Mubarak, has urged compromise and respect for election results. Egypt's 84 million people, control of the Suez Canal and treaty with Israel all contribute to its global strategic importance.

U.N. chief Ban Ki-moon urged Egyptians to respect "universal principles of peaceful dialogue" and to strengthen their democracy by promoting an "inclusive environment".

The European Union's foreign policy chief Catherine Ashton urged all sides to keep protests peaceful, build trust and show a "spirit of dialogue and tolerance".

In Alexandria, opposition marchers said they feared the Brotherhood was usurping the revolution to entrench its power and Islamic law. Others had economic grievances, among them huge lines for fuel caused by supply problems and panic buying.

"I've nothing to do with politics, but with the state we're in now, even a stone would cry out," said 42-year-old accountant Mohamed Abdel Latif. "There are no services, we can't find diesel or gasoline. We elected Mursi, but this is enough.

"Let him make way for someone else who can fix it."

It is hard to gauge how many may turn out on Sunday but much of the population, even those sympathetic to Islamic ideas, are frustrated by economic slump and many blame the government.

Previous protest movements since the fall of Mubarak have failed to gather momentum, however, among a population anxious for stability and fearful of further economic hardship.

(Additional reporting by Tom Perry, Alexander Dziadosz, Omar Fahmy and Alastair Macdonald in Cairo; Writing by Alastair Macdonald; Editing by Peter Graff)

Source: http://news.yahoo.com/egypt-clerics-warn-civil-war-urge-calm-102131532.html

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Babies can read each other?s moods, study finds

June 27, 2013 ? Although it may seem difficult for adults to understand what an infant is feeling, a new study from Brigham Young University finds that it's so easy a baby could do it.

Psychology professor Ross Flom's study, published in the academic journal Infancy, shows that infants can recognize each other's emotions by five months of age. This study comes on the heels of other significant research by Flom on infants' ability to understand the moods of dogs, monkeys and classical music.

"Newborns can't verbalize to their mom or dad that they are hungry or tired, so the first way they communicate is through affect or emotion," says Flom. "Thus it is not surprising that in early development, infants learn to discriminate changes in affect."

Infants can match emotion in adults at seven months and familiar adults at six months. In order to test infant's perception of their peer's emotions, Flom and his team of researchers tested a baby's ability to match emotional infant vocalizations with a paired infant facial expression.

"We found that 5 month old infants can match their peer's positive and negative vocalizations with the appropriate facial expression," says Flom. "This is the first study to show a matching ability with an infant this young. They are exposed to affect in a peer's voice and face which is likely more familiar to them because it's how they themselves convey or communicate positive and negative emotions."

In the study, infants were seated in front of two monitors. One of the monitors displayed video of a happy, smiling baby while the other monitor displayed video of a second sad, frowning baby. When audio was played of a third happy baby, the infant participating in the study looked longer to the video of the baby with positive facial expressions. The infant also was able to match negative vocalizations with video of the sad frowning baby. The audio recordings were from a third baby and not in sync with the lip movements of the babies in either video.

"These findings add to our understanding of early infant development by reiterating the fact that babies are highly sensitive to and comprehend some level of emotion," says Flom. "Babies learn more in their first 2 1/2 years of life than they do the rest of their lifespan, making it critical to examine how and what young infants learn and how this helps them learn other things."

Flom co-authored the study of 40 infants from Utah and Florida with Professor Lorraine Bahrick from Florida International University.

Flom's next step in studying infant perception is to run the experiments with a twist: test whether babies could do this at even younger ages if instead they were watching and hearing clips of themselves.

And while the talking twin babies in this popular YouTube clip are older, it's still a lot of fun to watch them babble at each other.

http://www.youtube.com/watch?feature=player_embedded&v=_JmA2ClUvUY

Source: http://feeds.sciencedaily.com/~r/sciencedaily/living_well/~3/ttEOJhEX-Xk/130627102835.htm

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